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| Gayle |
Gayle’s grandmother died young, possibly from a gynecologic cancer, and six months after her passing, her grandfather died suddenly while running for a bus. The four girls were now orphans. They were sent to live with an uncle and his son. When old enough, one of the girls, destined to be Gayle’s future mother, joined the Canadian Air Force.
The young girl was in El Paso visiting a friend from her military experience when she went on a blind date with a soldier from Fort Bliss. Wasting no time, the two were married two weeks later. They were together for fifty years before Gayle’s mother passed away with ovarian cancer. Her father (as of 2025) is 97 and is stubbornly still living by himself in Las Cruces, New Mexico; Gayle and her husband, Dr. Richard Murray, visit him often. While there, they sometimes enjoy a hike in the mountains.
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| Organ Mountains, Las Cruces, New Mexico (Credit: Loree Johnson) |
Gayle’s father came from a family of twelve, nearly all boys. They lived on a farm in Oklahoma. Life wasn't easy. His mother had married at thirteen and had her first child at sixteen. Her first husband died in the 1918 flu pandemic, the second died in a tractor accident, and the third became Gayle’s paternal grandfather.
Growing up in Texas, Gayle (she now knows) was a so-called FLK, the pediatrician’s affectionate acronym for a funny-looking kid, a child whose physical appearance suggests genetic health issues. Gayle had, in her words, “skinny, flat, and long feet,” and it was difficult for her mother to find shoes that fit her daughter properly. And, as a child, “the girl with the skinny legs” was often sickly and anemic. There was no medical explanation for this at the time, and satisfying answers wouldn’t be found until many years later (as we will see). Nonetheless, she had to adapt, to cope, without knowing why she had so many physical problems. She said that she read “the encyclopedias” in her search for answers and that this quest fueled her academic interests.
(Days after the interview, as I was “in the flow” listening intently to the recording, I was interrupted by a text from Gayle. Deeply absorbed in the engaging activity, I did not want to stop, but I paused to read the message. It turned out that the little girl who was left behind in Syria became a Catholic nun. She petitioned the Pope to allow her to travel to Canada and the U.S. to meet the family she never had the chance to know. Her petition was granted, and while here, she stayed with Gayle’s family for six weeks. After this, the family received letters from her–handwritten in Arabic and translated first into French and then English–for some years.)
Back to Gayle’s story. In college, she walked into a ballet class. It looked interesting, but it was full. The teacher asked her to jump as high as she could. She did that and showed her flexibility. The teacher quickly said, “Okay, you’re in.” Gayle said that, in her mind, she was just “extremely limber.”
When she was the first in her family to graduate from college, she wanted, she said, “to help people,” but she wasn’t sure what she would do to accomplish that. She had not actively thought about going into medicine until a medical school opened in Ciudad Juárez just across the Rio Grande in the state of Chihuahua, Mexico. Hearing about this, Gayle innocently thought to herself: “Huh! Maybe I’ll do that!”
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| Ciudad Juárez (Credit: world wonders) |
MCP (founded by Quaker men in 1850 as the first medical school in the world for women) it would be. By the time Dr. Andrews-Murray graduated four years later (in 1983), the gender split at the school was 60/40 in favor of women. When it was time to pick a residency, she chose to stay at the college. It turned out to be a good decision. You see, as an intern in the internal medicine program, one of her supervising residents was Dr. Richard Murray. He had been dating her girlfriend, and when she left MCP after graduation, Gayle, in her words, “moved in.” (Rich, as we have seen in a previous story in the series, remembers things differently.)
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| MCP class of 1891 (Credit: vintage everyday) |
During her training, she met endocrinologist Dr. Francine Camitta. Dr. Camitta had also been a Fellow at the University of Maryland with Dr. Connor and was practicing in York. She often came back to Baltimore to present interesting cases to her former (and, as we will learn, future) colleagues.
While Gayle and Rich were in Baltimore, “two boys came along,” she said. But having children did not come easily. Early on in the marriage, when conception did not happen, she saw a fertility specialist. She was diagnosed with extensive endometriosis; seven hours of delicate surgery allowed her to conceive. But with the first pregnancy, she had pre-term labor and was in the hospital for two months. She spent a week in the hospital waiting for her second son, but only needed medication to successfully carry the third.
While doing her three-year fellowship and raising two sons, Rich was in private practice and an attending physician at the university in downtown Baltimore. The family moved from an apartment outside the beltway to the city near the old Memorial Stadium. But as the neighborhood became progressively more dangerous, Gayle knew they had to move.
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| Memorial Stadium (Credit: Historic American Buildings Survey) |
(Many times, sitting across from Gayle as she told me her story, the connection was easy and open, and I momentarily forgot that she was a doctor.)
Frannie and Gayle were able to do private practice endocrinology and diabetes medicine together for a while, but as it became “harder to pay the bills” (without a lucrative “procedure” to supplement the office fees), they joined the nascent WellSpan Medical Group as the first subspecialty practice under contract. (The hospital needed to have an endocrinologist on staff to have an accredited Internal Medicine residency.).
| Dr. John Bobin |
After Dr. Bobin left the practice for a fellowship in cardiology, Gayle moved on. By then, she was able to go part-time with WellSpan, mostly taking care of complex patients with diabetes.
She took a hiatus from practice in 2006 when there were twelve surgeries in the family. Dr. Andrews-Murray said she used this time “to take care of everybody” and herself. When she was ready to return to medical practice, Dr. Oscar Murillo, who had formed a multispecialty group in Hanover, recruited her to be their endocrinologist. He was “a wonderful mentor and wonderful to all his patients,” said Gayle.
And by this time in her career, Gayle had developed an interest in reversing or even preventing diabetes rather than treating the late (and mostly unfixable) complications. She said that studies were being reported showing that early treatment with comprehensive lifestyle changes and substantial weight loss could allow the metabolic disorder to regress or disappear altogether.
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| Dr. Oscar Murillo |
As an example of the approach to promoting healthy habits through understanding, Gayle pointed out that “a carb is not a carb.” There are simple and complex carbohydrates, and the metabolic effects of each are different and vary according to what they are eaten with, what time of day they are consumed, and what you do after eating.
The glycemic index (introduced in 1981 and rating the effects of carbohydrates on a scale from 0 to 100) is a measurement of how quickly blood glucose rises after a specific food is eaten. If the index is high, the blood sugar rises very quickly. This is met by a vigorous outpouring of insulin from the pancreas to bring the (damaging) excessive glucose down and store it (for later use). But the blood glucose can then fall too low, resulting in counter-regulatory hormone release (including cortisol and adrenaline) with intense hunger (for more carbs) and fatigue about two hours after the meal. More carbohydrates are consumed, and the cycle continues.
To avoid the harmful spikes in blood glucose and high levels of insulin that follow a carb-laden breakfast, and that contribute to the development of insulin resistance leading to (among other maladies) diabetes, the metabolic syndrome, fatty liver, and cardiovascular disease. Dr. Andrews-Murray firmly recommends a routine of “no carbs before noon.” And she told me (hang on…) that “cold cereal in the morning is the worst time and the worst food you can eat.” If you must have it, she said, “eat it at lunch or dinner,” (when the body deals with nutrients differently, in accordance with the intrinsic circadian rhythm characteristic of all life on Earth).
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| Idealized blood glucose curves for foods with different glycemic indices (Credit: marleydrug.com) |
(Taking a walk or doing a few squats or calf-raises, or going to the gym after a good breakfast of bacon and eggs, also helps smooth out unhelpful metabolic fluctuations.)
As Dr. Andrews-Murray took care of patients in Dr. Murillo’s clinic in Hanover, everybody in the small cohesive group (all of the patients were employees of the hospital) had “a wonderful time.” She was, noted her husband, “excited” about how well her patients were doing. But after the grant money ran out and the hospital was acquired by UPMC (the huge healthcare system based in Pittsburgh), Dr. Andrews, she said, “had to move on.” Reflecting, she felt that this project was the “apex” of her career in medicine.
So Gayle retired from practice in 2017. And in 2025, eight years later, her careful scientific approach to treating and maybe preventing diabetes and its complications has become mainstream. She noted that it was discussed on "60 Minutes" (in October) when Dr. Peter Attia, best-selling author of Outlive, was interviewed about his comprehensive program for preventing or delaying many of the infirmities of old age.
Dr. Andrews-Murray lamented that many of the antidiabetic medicines she prescribed for her patients had troublesome side effects and did nothing to reverse the disease. She said that drugs like Ozempic (FDA-approved for type 2 diabetes in December 2017) are “very, very effective” and she would have “loved to have been able to use them” in her wellness clinic. However, she has some concerns about the adverse effects of these GLP-1 receptor agonists. Many patients experience nausea and vomiting with delayed emptying of the stomach. There may be significant muscle and bone loss, and there is the risk of nutritional deficiencies. And, rarely, some patients have had dangerous inflammation of the pancreas or ischemic optic neuropathy with potential blindness.
As noted above, Dr. Andrews-Murray had taken some time away from practice partly for her own health issues. As she was seeing Dr. Peter Rowe at the Johns Hopkins Ehlers-Danlos Syndrome (EDS) Clinic, and (among other things) showed him that she could touch her thumb to her forearm, he definitively diagnosed her as being on the hypermobility syndrome spectrum. Her findings were subtle and were easily overlooked by physicians for years (not uncommon in this hereditary but variable condition).
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| Classic simple example of hypermobility (Credit Franklin Cardiovascular Associates, PA) |
So, many of the problems Gayle has dealt with, including the allergy-like mast cell activation syndrome, inflammatory rheumatoid arthritis, the anemia and neuropathy of B12 deficiency, an underactive thyroid, areas of hair loss, and maybe even the extensive endometriosis that resulted in infertility, can be traced to her faulty hereditary disorder of connective tissue.
Though she was often tired of going to doctors in the past, and missed many visits, she is on top of things now and has willingly gone for screening tests to identify small problems (such as minor aneurysms) before they become big ones.
But EDS and its complications would not be the only health issues Dr. Andrews-Murray has had to endure. After she and her pulmonary specialist husband attended a medical meeting and sat around a table with his weary colleagues, everyone (are you ready for this?) developed COVID-19. Everyone. She responded to Paxlovid at first, but relapsed and was even sicker. She then developed a post-COVID syndrome (sometimes called long COVID) with prolonged cognitive and speech trouble. And fatigue. (The precise cause--or causes--of this remain unknown, but autoimmunity is suspected to play a major role.)
Gayle needed eight months of cognitive therapy and physical therapy, and eventually did well. But she still copes with intermittent brain fog and mental fatigue. And when she had a second bout of COVID after flying out west to see her father, her rheumatoid arthritis flared up.
On a lighter note, Gayle’s three sons, without specific encouragement from Gayle or Rich, chose to go into medicine. One of them is in a serious relationship with a woman physician. So, at some point in the future, there might be six doctors in the family. Maybe even more. Who knows?
To close, an interesting connection across time and space:
One of Gayle’s close colleagues when she was with WellSpan was Dr. Rita El-Hajj. Rita is from Beirut and now practices endocrinology in Wynnwood, just outside of Philly. Her parents were visiting from Lebanon, and Gayle and Rich were invited to meet them. They said they were from Zahlé — the very same city where Gayle’s ancestors had lived when it was still part of Syria. Rita’s parents knew Gayle’s family and told her there was a statue of Gayle’s great-great-grandfather there — he was a doctor.
Suggested Readings:
1. Attia, Peter M.D., with Bill Gifford. Outlive: The Science & Art of Longevity. New York: Random House, 2023. (An in-depth plea and detailed outline for what he calls Medicine 3.0, the idea that chronic illness can and should be prevented rather than treated. A big book of 470 pages, but essential reading.)
2. Duhigg, Charles. The Power of Habit: Why We Do What We Do in Life and Business. New York: Random House, 2012. (Recommended by Gayle after our interview. Quoting William James, Duhigg wrote: "Habits are what allow us to 'do a thing with difficulty the first time, but soon do it...with hardly any consciousness at all.'" p. 273)
3. Hideaki Oike, Katsutaka Oishi, and Masuko Kobori. "Nutrients, Clock Genes, and Chrononutrition. "Curr Nutr Rep (2014) 3:204–212. ("Because the circadian system organizes whole energy homeostasis, including food intake, fat accumulation, and caloric expenditure, the disruption of circadian clocks leads to metabolic disorders." p. 204)
By Anita Cherry 11/14/25
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